Cola óssea para tratamento de fraturas – Blog Famara

Cola óssea: Um novo tipo de cola está sendo testado no espaço para ver como o material se comporta longe da superfície da Terra. A cola é feita de cálcio e aminoácidos, e é chamada de Tetranite. Com ela, fraturas complicadas, como as de quem sofre de osteoporose, poderiam ser coladas rapidamente, sem a ajuda de parafusos e placas metálicas.

Outro possível uso para o material é gerar a produção de novo material ósseo em pessoas, também útil em quem tem osteoporose e para astronautas, que podem perder 2% da massa óssea a cada mês que passam longe da superfície da Terra. Por isso, o Tetranite foi enviado para a Estação Espacial Internacional à bordo da capsula Dragon da SpaceX no último dia 15 de dezembro, para ser observado no espaço.

“Se conseguirmos mostrar que nosso material simula a produção de osso novo no ambiente espacial, isso terá um grande valor na Terra, pois poderia ser usado algum dia para tratar pacientes com osteoporose. Mas também poderia ser um material para tratar astronautas dos efeitos de longas viagens espaciais. Este é obviamente um motivo secundário para estudar a cola no espaço, mas é uma dualidade interessante”, diz Brian Hess, CEO da empresa Launchpad Medical, que desenvolveu a cola.

No experimento na EEI, astronautas estão trabalhando com testes em culturas de células com o Tetranito. Essas culturas estão sendo manipuladas na Microgravity Science Globebox (Caixa de Luvas Científica de Microgravidade), equipamento instalado na EEI que fornece um ambiente completamente selado com luvas embutidas para que os materiais sejam manipulados.

O experimento tem previsão de duração de 20 dias, e depois será congelado e enviado de voltar à Terra ainda no mês de janeiro, quando o Dragon deve voltar para os Estados Unidos com mais de 1.600kg de materiais de pesquisa, equipamentos e outros materiais. O mesmo estudo está acontecendo simultaneamente na Terra, para que os resultados sejam comparados.

Se os resultados forem promissores, testes mais longos devem acontecer no centro de pesquisa com roedores da EEI. A empresa já usou a cola com sucesso em roedores na Terra para estabilizar implantes dentários. A intenção é testar o material em seres humanos daqui a um ano.

Os resultados deste experimento serão muito importantes para a NASA, que tem estudado os efeitos da perda de massa óssea em astronautas há anos. Os estudos mais famosos da agência incluem manter os voluntários deitados em camas por 90 dias, simulando os efeitos da microgravidade em que a falta de gravidade da Terra prejudica o processo de manutenção dos ossos.

Um processo semelhante é observado em quem sofre com a osteoporose, doença em que o osso é reabsorvido em ritmo maior do que a formação de novo osso acontece. Apenas no Brasil, 10 milhões de pessoas têm o problema, sendo que uma em cada três mulheres com mais de 50 anos tem a doença. Em nosso país, 2,4 milhões de fraturas acontecem por ano por conta da osteoporose, e 200 mil pessoas morrem todos os anos por causa dessas fraturas de ossos importantes, como fêmur, coluna vertebral e quadril.

Hess diz que a ideia de usar parafusos e placas de metal para segurar ossos parece muito antiquada. “Eles [cirurgiões] estão usando tecnologia antiquada. Eu sabia que tinha que ter um jeito menos invasivo e mais elegante para fazer isso”. A cola óssea foi inspirada no material produzido pro cracas para se fixarem em rochas e cascos de embarcações.

“O cálcio e o aminoácido reagem para formar uma substância grudenta que fica dura. Com o tempo essa cola é reabsorvida pelo corpo”, explica ele. O material não é rejeitado pelo corpo e, por ser sintético, não tem alto custo de produção. [Firme Forte OsteoporoseSeeker]

Confira abaixo vídeo publicado pela Launchpad Medical, desenvolvedora da cola óssea:

Fonte: HypeScience

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